Techniques and Assays
Analytical Methods
UV, HPLC, LC-MS, LC-MSMS
Enzyme immunoassay and ELISA
Projects requiring other analytical methods, e.g. gas chromatography may be accommodated upon request
In-vitro ADME Assays
Absorption studies using PAMPA, CACO-2, PGP and other transporter enzyme assays
Metabolism studies using cyp450 enzymes, microsomes, S9, cytosol or hepatocytes
Metabolic route determination using inhibitory antibodies, probes or correlation analysis
Distribution: protein binding (equilibrium dialysis), tissue binding
Inhibition: p450 inhibition via pooled probes or custom substrates
Sample Matrices
Biological, environmental, pharmaceuticals, food products. etc.
Today's techniques for tomorrow's solutions.